Biotech

Committed to addressing critical technical challenges in modern healthcare. This team of biomedical engineers, molecular biologists, materials scientists, chemists and biophysicists drive advancements in medical technology through close partnerships with clinicians and external researchers.

Capabilities

  • Wound Healing

    Advanced regenerative and therapeutic materials for wound healing and pain management. We leverage advancements in nanofiber, hydrogel, and liposome-based technologies to provide new solutions for treating burns, preventing postoperative adhesions, repairing ocular surfaces, and delivering cell-based therapies.

    Recent Patents, Patent Applications, Publications and Presentations

    • Costella, L. Tison, C.K., Patterson, M., Broderick, K. (2019). Nanofiber-reinforced Hydrogel Medical Dressings. PCT/US2019/026254.
    • Costella, L. Danilich, M. Tison, C. Cottler, P. (2019) Sprayable barrier and Methods for Prevention of Postoperative Adhesions. PCT/US2018/024716. USPTO Application 16/500,556.
    • L. Woodard, L. Costella, M. Gasbarre, B. Janet, C.K. Tison. (2019). “Hydrogel Scaffolds for the Controlled Regeneration of Osteochondral Injuries.” Military Health Systems Research Symposium. Kissimmee, FL. Poster Presentation.
  • Clinical & Environmental Diagnostics

    State-of-the-art assay and diagnostic systems for accurate and rapid detection of chemical, biological, and environmental threats. We take conceptual designs for detection and integrate unique assays to deliver functional and deployable systems. Recent developments include novel point-of-care viral serodiagnostic and avidity assays, rapid and automated E. coli detection, and dissolvable specimen-capture swab products.

    Recent Patents, Patent Applications, Publications and Presentations

    • Tison, C.K., Butler, B., Patterson, M., Braun, N. (2018) Dissolvable Nanofiber Materials and Specimen Recovery Kits Including the Same for High Efficiency Specimen Recovery. PCT Application WO 2018/132233 A1. UPSTO Application 16/470,668.
    • N. Talley, N. Braun, J. Hinton, M. Desrosiers, S. Minavio, D. Ceriani, C.K. Tison. (2019). “E.coREADi: Automated Microbiological Water Analysis.” US EPA Decontamination R&D Conference. Norfolk, VA. Poster Presentation. 
    • N. Braun, B. Butler, V. Stagnaro, C.K. Tison. (2017). “Dissolvable Swabs for use in Forensic Evidence Collection.” International Association of Forensic Sciences. Toronto, Canada. Poster Presentation.
  • Medical Simulation

    Life-like materials and systems for medical simulation, applying biomechanics, computational modeling, and materials engineering to create new products. Recent product development efforts include a task trainer for realistic joint reduction training, a dynamic skin model for testing of less-than-lethal projectiles, and Luna’s expanding product line of TrueClot bleeding control training products.

    Recent Patents, Patent Applications, Publications and Presentations

    • M. DeWitt, M. Danilich, K. Kong, M.B. Panzer, C. Bir, and B. Gillich. (2020) “Development of a Physical and Mathematical Ballistic Skin Simulant.”  International Personal Armour Committee (IPAC) – Personal Armour Systems Symposia (PASS). Copenhagen, DK. Oral Presentation and Full Paper.
    • K. Kong, M. DeWitt, M. Danilich, B. Gillich, M. B. Panzer. (2020) “Dynamic Mechanical Properties of Human Skin and the Development of a Damage-Predicting Constitutive Model.”  International Personal Armour Committee (IPAC) – Personal Armour Systems Symposia (PASS). Copenhagen, DK. Oral Presentation and Full Paper.
    • Virgilio, K., Patterson, M., Hackett, M., Remer, D., Jansen, J., Day, B., Tison, C. (2020) “Joint Reduction Platform for Realistic Training.” Military Health System Research Symposium. Orlando, FL. Poster Presentation.
       

     

  • Human Performance

    Biophysics-driven solutions for health monitoring, human interfacing, and improved performance. Our team combines principles of physics, mechanics, electrics, and acoustics to rationally design technologies that enhance key biological functions for those on the front lines of defense and healthcare. Recent developments include wearable hydration monitors, endurance support systems, neural interfaces, and biomechanical models of pain. 

    Recent Patents, Patent Applications, Publications, and Presentations

    • Costella, L. Tison, C.K., Skoff, M. Remer, D. (2019). Ultra-flexible Neural Interfacing Materials. Provisional Patent Application No. 62814385. 
    • D. Remer, L. Costella, K. Yoshida, A. Joshi-Imre, C.K. Tison. (2019). “Flexible Low-Modulus Nanofiber-Based TIME Nerve Interfaces.” Society for Biomaterials. Seattle, WA. Podium Presentation.
    • L. Costella, K. Mangham, M. Skoff, K. Yoshida, C.K. Tison. (2017). “Nanofiber Based Materials for Neural Interfacing.” Society for Biomaterials. Minneapolis, MN. Poster Presentation.
  • Drug & Vaccine Delivery

    Drug delivery systems to treat diverse injuries and diseases. Our team establishes new solutions for targeted therapeutic release, stabilization of vaccines, and sustained drug release agents. Some of Luna’s novel technologies include nasal-delivered liposomes for brain injury and anti-Tuberculosis (TB) gummy bears for pediatrics.

    Recent Patents, Patent Applications, Publications, and Presentations

    • Y. Xu, B. Brooks, Z. Zhou, T. Ferguson, X. Kong, C.K. Tison. (2019). “Carbon Nanotubes as a Novel HIV-1 Vaccine Antigen Vector for Mucosal Immunity Stimulation.” Military Health Systems Research Symposium. Kissimmee, FL. Poster Presentation.
    • Y. Xu, B. Brooks, Z. Zhou, J. Miller, C.K. Tison (2018). “Bioinspired Synthetic Nanoparticles as Universal Antivenom.” 2018 Defense TechConnect Fall Conference & Expo, Tampa, FL. Poster Presentation.